• 1
    Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K. et al., Cloning of a new cytokine that induces interferon-γ. Nature 1995. 378: 8891.
  • 2
    Puren, A. J., Fantuzzi, G. and Dinarello, C. A., Gene expression, synthesis and secretion of IL-1β and IL-18 are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA 1999. 96: 22562261.
  • 3
    Pizarro, T. T., Michie, M. H., Bentz, M., Woraratanadharm, J., Smith, M. F., Jr., Foley, E., Moskaluk, C. A. et al., IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J. Immunol. 1999. 162: 68296835.
  • 4
    Cohen, I., Rider, P., Carmi, Y., Braiman, A., Dotan, S., White, M. R., Voronov, E. et al., Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc. Natl. Acad. Sci. USA 2010. 107: 25742579.
  • 5
    Rider, P., Carmi, Y., Guttman, O., Braiman, A., Cohen, I., Voronov, E., White, M. R. et al., IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol. 2011. 187: 48354843.
  • 6
    Sugawara, S., Uehara, A., Nochi, T., Yamaguchi, T., Ueda, H., Sugiyama, A., Hanzawa, K. et al., Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J. Immunol. 2001. 167: 65686575.
  • 7
    Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S. C. and Dinarello, C. A., Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 1990. 75: 4047.
  • 8
    Netea, M. G., Nold-Petry, C. A., Nold, M. F., Joosten, L. A., Opitz, B., van der Meer, J. H., van de Veerdonk, F. L. et al., Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009. 113: 23242335.
  • 9
    Andrei, C., Dazzi, C., Lotti, L., Torrisi, M. R., Chimini, G. and Rubartelli, A., The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell 1999. 10: 14631475.
  • 10
    Andrei, C., Margiocco, P., Poggi, A., Lotti, L. V., Torrisi, M. R. and Rubartelli, A., Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc. Natl. Acad. Sci. USA 2004. 101: 97459750.
  • 11
    Bellora, F., Castriconi, R., Doni, A., Cantoni, C., Moretta, L., Mantovani, A., Moretta, A. et al., M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages. Eur. J. Immunol., 2012. 42: 1618-1626.
  • 12
    Kurt-Jones, E. A., Beller, D. I., Mizel, S. B. and Unanue, E. R., Identification of a membrane-associated interleukin-1 in macrophages. Proc. Natl. Acad. Sci. USA 1985. 82: 12041208.
  • 13
    Kaplanski, G., Farnarier, C., Kaplanski, S., Porat, R., Shapiro, L., Bongrand, P. and Dinarello, C. A., Interleukin-1 induces interleukin-8 from endothelial cells by a juxacrine mechanism. Blood 1994. 84: 42424248.
  • 14
    Stevenson, F. T., Bursten, S. L., Fanton, C., Locksley, R. M. and Lovett, D. H., The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc. Natl. Acad. Sci. USA 1993. 90: 72457249.
  • 15
    Mazodier, K., Marin, V., Novick, D., Farnarier, C., Robitail, S., Schleinitz, N., Veit, V. et al., Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood 2005. 106: 34833489.
  • 16
    Doyle, S. L., Campbell, M., Ozaki, E., Salomon, R. G., Mori, A., Kenna, P. F., Farrar, G. J. et al., NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat. Med. 2012, in press.
  • 17
    Siegmund, B., Interleukin-18 in intestinal inflammation: friend and foe? Immunity 2010. 32: 300302.
  • 18
    Dinarello, C. A., Interleukin-18 and the pathogenesis of inflammatory diseases. Semin. Nephrol. 2007. 27: 98114.
  • 19
    Netea, M. G., Joosten, L. A., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J. et al., Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat. Med. 2006. 12: 650656.