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Figure S1. IL-17, IL-22, and IFN-γ concentrations in culture supernatants of CD4 cells (5 × 105) stimulated for 7 days with medium, IL-36β or IL-36γ. Concentrations of IL-36 cytokines range from 1 to 100 ng/mL.

Figure S2. IL-12Rβ1, IL-1R1, and IL-18Rα expression on CD4 T cells and total PBMCs (n = 4 donors) stimulated for 7 days with A. fumigatus in the presence or absence of IL-36Ra (concentration ranging from 0.1 to 100 ng/mL). Whole PBMCs were stained with anti-CD4, anti-IL-12Rβ1, anti-IL-1R1, and anti-IL-18Rα. CD4 positive population was gated and subsequently the percentage of positive cells for each of the receptors was determined.

Figure S3. IL-18 and IL-12p35 mRNA expression in PBMCs stimulated for 24h with 1 × 107/mL Aspergillus conidia or hyphae in the presence or absence or IL-36Ra in concentrations ranging from 1 to 100 ng/mL.

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