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eji2464-sup-0001-FigureS1.pdf343KSupplementary Fig. 1 Qa-1-restriction pp y g Q of GA-induced CD8+ regulatory T cells Colitis was induced in C57BL/6 mice by administration of 2% DSS in the drinking water, CD8+ T cells enriched from mesenteric lymph nodes of GA-vaccinated WT and Qa-1-/- mice were transferred into recipients (i.v. 106 cells per mouse) on the day of disease induction. Mice injected with na・e WT or Qa-1-/- CD8+ T cells were used as control. (A) Relative weight; (B) disease activity index; (C) representative photomicrographs and (D) scores of histological features from colons 9 days after DSS induction. Error bars indicate the SD. Similar results were observed in two independent experiments (with 5 mice per group). (Mann-Whitney test,*p < 0.05)

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