ICOS controls Foxp3+ regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
Article first published online: 31 JAN 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 43, Issue 3, pages 705–715, March 2013
How to Cite
Redpath, S. A., van der Werf , N., Cervera, A. M., MacDonald, A. S., Gray, D., Maizels, R. M. and Taylor, M. D. (2013), ICOS controls Foxp3+ regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur. J. Immunol., 43: 705–715. doi: 10.1002/eji.201242794
- Issue published online: 11 MAR 2013
- Article first published online: 31 JAN 2013
- Accepted manuscript online: 14 JAN 2013 09:06AM EST
- Manuscript Accepted: 12 DEC 2012
- Manuscript Revised: 28 NOV 2012
- Manuscript Received: 4 JUL 2012
- Medical Research Council UK. Grant Number: G0600112
- RMM by the Wellcome Trust. Grant Number: 090281
- Strategic award from the Wellcome Trust for the Centre for Immunity, Infection, and Evolution. Grant Number: 095831
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Figure S1. ICOS deficiency does not affect susceptibility to H. polygyrus or S. mansoni infections, or S. mansoni-mediated pathology.
Figure S2. H. polygyrus infection expands both Helios+ and Helios- Foxp3+ Tregs in the MLN.
Figure S3. Representative FC staining for Foxp3 and IL-10 on LP CD4+ T cells.
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