The copyright line of the above article has been changed since first published on 13 December 2012. The correct copyright of this article is:
Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis
Article first published online: 13 DEC 2012
© 2012 The Authors. European Journal of Immunology published by Wiley-VCH Verlag GmbH & Co. KGaA Weinheim.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
European Journal of Immunology
Volume 43, Issue 2, pages 540–549, February 2013
How to Cite
Kalsdorf, B., Skolimowska, K. H., Scriba, T. J., Dawson, R., Dheda, K., Wood, K., Hofmeister, J., Hanekom, W. A., Lange, C. and Wilkinson, R. J. (2013), Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis. Eur. J. Immunol., 43: 540–549. doi: 10.1002/eji.201242804
- Issue published online: 14 FEB 2013
- Article first published online: 13 DEC 2012
- Accepted manuscript online: 12 NOV 2012 06:24AM EST
- Manuscript Accepted: 5 NOV 2012
- Manuscript Revised: 27 SEP 2012
- Manuscript Received: 1 JUL 2012
- German Research Foundation. Grant Number: DFG SCHE1556
- German National Respiratory Society
- Wellcome Trust. Grant Numbers: 088316, 080929, 084323
- Aeras Global TB Vaccine Foundation, Gates Foundation
- NIH. Grant Numbers: RO1-AI-087915, NO1-AI-70022
- HW & J Hector Foundation, Weinheim, Germany
- MRC. Grant Number: U.1175.02.002.00014.01
- European Union. Grant Number: Sante/2006/105-061
- Viral load
Increased susceptibility to tuberculosis following HIV-1 seroconversion contributes significantly to the tuberculosis epidemic in sub-Saharan Africa. Lung-specific mechanisms underlying the interaction between HIV-1 and Mycobacterium tuberculosis infection are incompletely understood. Here we address these questions by examining the effect of HIV-1 and latent M. tuberculosis co-infection on the expression of viral-entry receptors and ligands in bronchoalveolar lavage (BAL) of HIV-1-infected and -uninfected patients with and without latent M. tuberculosis infection.
Irrespective of HIV-1 status, T cells from BAL expressed higher levels of the beta-chemokine receptor (CCR)5 than peripheral blood T cells, in particular the CD8+ T cells of HIV-1-infected persons showed elevated CCR5 expression. The concentrations of the CCR5 ligands RANTES and MIP-1β were elevated in the BAL of HIV-1-infected persons compared with that in HIV-1-uninfected controls. CCR5 expression and RANTES concentration correlated strongly with HIV-1 viral load in the BAL. In contrast, these alterations were not associated with M. tuberculosis sensitisation in vivo, nor did M. tuberculosis infection of BAL cells ex vivo change RANTES expression.
These data suggest ongoing HIV-1 replication predominantly drives local pulmonary CCR5+ T-cell activation in HIV/latent M. tuberculosis co-infection.