Tc9 cells, a new subset of CD8+ T cells, support Th2-mediated airway inflammation
Article first published online: 31 JAN 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 43, Issue 3, pages 606–618, March 2013
How to Cite
Visekruna, A., Ritter, J., Scholz, T., Campos, L., Guralnik, A., Poncette, L., Raifer, H., Hagner, S., Garn, H., Staudt, V., Bopp, T., Reuter, S., Taube, C., Loser, K. and Huber, M. (2013), Tc9 cells, a new subset of CD8+ T cells, support Th2-mediated airway inflammation. Eur. J. Immunol., 43: 606–618. doi: 10.1002/eji.201242825
- Issue published online: 11 MAR 2013
- Article first published online: 31 JAN 2013
- Accepted manuscript online: 19 DEC 2012 02:08AM EST
- Manuscript Accepted: 13 DEC 2012
- Manuscript Revised: 7 DEC 2012
- Manuscript Received: 13 JUL 2012
- Deutsche Forschungsgemeinschaft. Grant Numbers: HU 1824/2–1, SFB/TR22, LO 817/2–1, SCHM 1014/5–1
- International Graduate School of Immunotherapy
- Interdisciplinary Center of Clinical Research. Grant Number: Lo2/004/11
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Figure S1. Flow cytometric analysis of OT-l-Tc9 cells.
Figure S2. Enforced Foxp3 expression suppresses IL-9 production in CD8+ T cells cultured under TGFp and IL-4 conditions.
Figure S3. Rag2A mice received PBS, Th2 cells derived from purified CD4+ T cells from OT-II mice alone or in combination with Tc9 cells derived from purified CD8+ T cells from OT-I mice on day 0.
Figure S4. Transferred CD8+ T cells isolated form the lungs of diseased Rag2A mice express IFN-g and to lower extent IL-13.
Figure S5. Isotype control stainings for CD8 and IL-9 of mouse and human cells.
Table S1. qPCR primers.
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