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Figure S1. AdipoR1 and R2 are expressed by murine lymph node cells and splenocytes.

Figure S2. Higher proliferation of ADPKO CD4+ T cell compared to WT CD4+ T cells in response to anti-CD3 stimulation in the absence of APCs.

Figure S3. Naïve ADPKO T cells are more activated than naïve WT T cells.

Figure S4. Numbers of Treg cells in naïve WT and ADPKO mice.

Figure S5. Treatment with gADP led to adenosine monophosphate (AMP)-activated protein kinase (AMPK) activation in vivo.

Figure S6. gADP does not affect the conversion of naïve T cell into Treg in vitro.

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