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  • 1
    Ahmed, R. and Gray, D., Immunological memory and protective immunity: understanding their relation. Science 1996. 272: 5460.
  • 2
    Zhu, J. and Paul, W. E., CD4 T cells: fates, functions, and faults. Blood 2008. 112: 15571569.
  • 3
    Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L., Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 23482357.
  • 4
    Seder, R. A., Gazzinelli, R., Sher, A. and Paul, W. E., Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 1993. 90: 1018810192.
  • 5
    Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655669.
  • 6
    Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y. et al., Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996. 382: 171174.
  • 7
    Schulz, E. G., Mariani, L., Radbruch, A. and Hofer, T., Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 2009. 30: 673683.
  • 8
    Lohning, M., Richter, A. and Radbruch, A., Cytokine memory of T helper lymphocytes. Adv. Immunol. 2002. 80: 115181.
  • 9
    Wilson, C. B., Rowell, E. and Sekimata, M., Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 2009. 9: 91105.
  • 10
    Melvin, A. J., McGurn, M. E., Bort, S. J., Gibson, C. and Lewis, D. B., Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells. Eur. J. Immunol. 1995. 25: 426430.
  • 11
    Dong, J., Ivascu, C., Chang, H. D., Wu, P., Angeli, R., Maggi, L., Eckhardt, F. et al., IL-10 is excluded from the functional cytokine memory of human CD4+ memory T lymphocytes. J. Immunol. 2007. 179: 23892396.
  • 12
    Mikovits, J. A., Young, H. A., Vertino, P., Issa, J. P., Pitha, P. M., Turcoski-Corrales, S. et al., Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. Mol. Cell Biol. 1998. 18: 51665177.
  • 13
    Lee, D. U., Avni, O., Chen, L. and Rao, A., A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J. Biol. Chem. 2004. 279: 48024810.
  • 14
    Penix, L. A., Sweetser, M. T., Weaver, W. M., Hoeffler, J. P., Kerppola, T. K. and Wilson, C. B., The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. J. Biol. Chem. 1996. 271: 3196431972.
  • 15
    Soutto, M., Zhang, F., Enerson, B., Tong, Y., Boothby, M. and Aune, T. M., A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol. 2002. 169: 42054212.
  • 16
    Bird, J. J., Brown, D. R., Mullen, A. C., Moskowitz, N. H., Mahowald, M. A., Sider, J. R., Gajewski, T. F. et al., Helper T-cell differentiation is controlled by the cell cycle. Immunity 1998. 9: 229237.
  • 17
    Richter, A., Lohning, M. and Radbruch, A., Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 1999. 190: 14391450.
  • 18
    Letimier, F. A., Passini, N., Gasparian, S., Bianchi, E. and Rogge, L., Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation. EMBO J. 2007. 26: 12921302.
  • 19
    Stobie, L., Gurunathan, S., Prussin, C., Sacks, D. L., Glaichenhaus, N., Wu, C. Y. and Seder, R. A., The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl. Acad. Sci. USA 2000. 97: 84278432.
  • 20
    Park, A. Y., Hondowicz, B. D. and Scott, P., IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 2000. 165: 896902.
  • 21
    Yap, G., Pesin, M. and Sher, A., Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 2000. 165: 628631.
  • 22
    Jacobson, N. G., Szabo, S. J., Weber-Nordt, R. M., Zhong, Z., Schreiber, R. D., Darnell, J. E., Jr. and Murphy, K. M., Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 1995. 181: 17551762.
  • 23
    Janossy, G., Panayi, G., Duke, O., Bofill, M., Poulter, L. W. and Goldstein, G., Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet 1981. 2: 839842.
  • 24
    Firestein, G. S., Immunologic mechanisms in the pathogenesis of rheumatoid arthritis. J. Clin. Rheumatol. 2005. 11: S3944.
  • 25
    Sallusto, F., Geginat, J. and Lanzavecchia, A., Central memory and effector memory T-cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745763.
  • 26
    Schoenborn, J. R., Dorschner, M. O., Sekimata, M., Santer, D. M., Shnyreva, M., Fitzpatrick, D. R., Stamatoyannopoulos, J. A. and Wilson, C. B., Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat. Immunol. 2007. 8: 732742.
  • 27
    Collins, P. L., Henderson, M. A. and Aune, T. M., Diverse functions of distal regulatory elements at the IFNG locus. J. Immunol. 2012. 188: 17261733.
  • 28
    Winders, B. R., Schwartz, R. H. and Bruniquel, D., A distinct region of the murine IFN-gamma promoter is hypomethylated from early T-cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J. Immunol. 2004. 173: 73777384.
  • 29
    Jones, B. and Chen, J., Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J. 2006. 25: 24432452.
  • 30
    Bird, A., DNA methylation patterns and epigenetic memory. Genes Dev. 2002. 16: 621.
  • 31
    Gjerset, R. A. and Martin, D. W., Jr., Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells. J. Biol. Chem. 1982. 257: 85818583.
  • 32
    Oswald, J., Engemann, S., Lane, N., Mayer, W., Olek, A., Fundele, R., Dean, W., Reik, W. and Walter, J., Active demethylation of the paternal genome in the mouse zygote. Curr. Biol. 2000. 10: 475478.
  • 33
    Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R. and Greenberg, M. E., Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003. 302: 885889.
  • 34
    Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G. and Sun, Y. E., DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 2003. 302: 890893.
  • 35
    Bruniquel, D. and Schwartz, R. H., Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol. 2003. 4: 235240.
  • 36
    Murayama, A., Sakura, K., Nakama, M., Yasuzawa-Tanaka, K., Fujita, E., Tateishi, Y., Wang, Y. et al., A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J. 2006. 25: 10811092.
  • 37
    Klug, M., Heinz, S., Gebhard, C., Schwarzfischer, L., Krause, S. W., Andreesen, R. and Rehli, M., Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol. 2010. 11: R63.
  • 38
    Kim, M. S., Kondo, T., Takada, I., Youn, M. Y., Yamamoto, Y., Takahashi, S., Matsumoto, T. et al., DNA demethylation in hormone-induced transcriptional derepression. Nature 2009. 461: 10071012.
  • 39
    Kress, C., Thomassin, H. and Grange, T., Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks. Proc. Natl. Acad. Sci. USA 2006. 103: 1111211117.
  • 40
    Popp, C., Dean, W., Feng, S., Cokus, S. J., Andrews, S., Pellegrini, M., Jacobsen, S. E. and Reik, W., Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 2010. 463: 11011105.
  • 41
    Bhutani, N., Brady, J. J., Damian, M., Sacco, A., Corbel, S. Y. and Blau, H. M., Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010. 463: 10421047.
  • 42
    Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S. et al., Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009. 324: 930935.
  • 43
    Ito, S., D'Alessio, A. C., Taranova, O. V., Hong, K., Sowers, L. C. and Zhang, Y., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010. 466: 11291133.
  • 44
    Metivier, R., Gallais, R., Tiffoche, C., Le Peron, C., Jurkowska, R. Z., Carmouche, R. P., Ibberson, D. et al., Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008. 452: 4550.
  • 45
    Eivazova, E. R. and Aune, T. M., Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Proc. Natl. Acad. Sci. USA 2004. 101: 251256.
  • 46
    Wei, L., Vahedi, G., Sun, H. W., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H. et al., Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 2010. 32: 840851.
  • 47
    Wu, C. Y., Kirman, J. R., Rotte, M. J., Davey, D. F., Perfetto, S. P., Rhee, E. G., Freidag, B. L. et al., Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo. Nat. Immunol. 2002. 3: 852858.
  • 48
    Tykocinski, L. O., Hajkova, P., Chang, H. D., Stamm, T., Sozeri, O., Lohning, M., Hu-Li, J. et al., A critical control element for interleukin-4 memory expression in T helper lymphocytes. J. Biol. Chem. 2005. 280: 2817728185.
  • 49
    Morinobu, A., Kanno, Y. and O'Shea, J. J., Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. J. Biol. Chem. 2004. 279: 4064040646.
  • 50
    Borger, P., Kauffman, H. F., Postma, D. S. and Vellenga, E., Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 1996. 87: 691698.
  • 51
    Kimmig, S., Przybylski, G. K., Schmidt, C. A., Laurisch, K., Mowes, B., Radbruch, A. and Thiel, A., Two subsets of naive T helper cells with distinct T-cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 2002. 195: 789794.