• 1
    Roep, B. O., Arden, S. D., de Vries, R. R.andHutton, J. C., T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 1990. 345: 632634.
  • 2
    Keymeulen, B., Walter, M., Mathieu, C., Kaufman, L., Gorus, F., Hilbrands, R., Vandemeulebroucke, E. et al., Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 2010. 53: 614623.
  • 3
    Ludvigsson, J., Faresjo, M., Hjorth, M., Axelsson, S., Cheramy, M., Pihl, M., Vaarala, O. et al., GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008. 359: 19091920.
  • 4
    Orban, T., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A. et al., Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 2011. 378: 412419.
  • 5
    Pescovitz, M. D., Greenbaum, C. J., Krause-Steinrauf, H., Becker, D. J., Gitelman, S. E., Goland, R., Gottlieb, P. A. et al., Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N. Engl. J. Med. 2009. 361: 21432152.
  • 6
    Roep, B. O., New hope for immune intervention therapy in type 1 diabetes. Lancet 2011. 378: 376378.
  • 7
    Roep, B. O. and Peakman, M., Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes. Nat. Rev. Immunol. 2010. 10: 145152.
  • 8
    Mellman, I. and Steinman, R. M., Dendritic cells: specialized and regulated antigen processing machines. Cell 2001. 106: 255258.
  • 9
    Lutz, M. B. andSchuler, G., Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002. 23: 445449.
  • 10
    Giannoukakis, N., Phillips, B., Finegold, D., Harnaha, J., and Trucco, M., Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care 2011. 34: 20262032.
  • 11
    Unger, W. W., Laban, S., Kleijwegt, F. S., van der Slik, A. R., and Roep, B. O., Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1. Eur. J. Immunol. 2009. 39: 31473159.
  • 12
    van Halteren, A. G., Tysma, O. M., van, E. E., Mathieu, C. and Roep, B. O., 1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis. J. Autoimmun. 2004. 23: 233239.
  • 13
    Kleijwegt, F. S., Laban, S., Duinkerken, G., Joosten, A. M., Koeleman, B. P., Nikolic, T. and Roep, B. O., Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells. J. Immunol. 2011. 187: 63576364.
  • 14
    Willcox, A., Richardson, S. J., Bone, A. J., Foulis, A. K. and Morgan, N. G., Analysis of islet inflammation in human type 1 diabetes. Clin. Exp. Immunol. 2009. 155: 173181.
  • 15
    Coppieters, K. T., Dotta, F., Amirian, N., Campbell, P. D., Kay, T. W., Atkinson, M. A., Roep, B. O. et al., Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 2012. 209: 5160.
  • 16
    Skowera, A., Ellis, R. J., Varela-Calvino, R., Arif, S., Huang, G. C., Van-Krinks, C., Zaremba, A. et al., CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J. Clin. Invest. 2008. 118: 33903402.
  • 17
    Curtsinger, J. M., Lins, D. C. and Mescher, M. F., Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J. Exp. Med. 2003. 197: 11411151.
  • 18
    Chamorro, S., Garcia-Vallejo, J. J., Unger, W. W., Fernandes, R. J., Bruijns, S. C., Laban, S., Roep, B. O. et al., TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program. J. Immunol. 2009. 183: 29842994.
  • 19
    Kleijwegt, F. S., Laban, S., Duinkerken, G., Joosten, A. M., Zaldumbide, A., Nikolic, T. and Roep, B. O., Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J. Immunol. 2010. 185: 14121418.
  • 20
    Bots, M., VAN, B. L., Rademaker, M. T., Offringa, R. and Medema, J. P., Serpins prevent granzyme-induced death in a species-specific manner. Immunol. Cell Biol. 2006. 84: 7986.
    Direct Link:
  • 21
    Ferreira, G. B., Kleijwegt, F. S., Waelkens, E., Lage, K., Nikolic, T., Hansen, D. A., Workman, C. T. et al., Differential protein pathways in 1,25-dihydroxyvitamin D(3) and dexamethasone modulated tolerogenic human dendritic cells. J. Proteome. Res. 2012. 11: 941971.
  • 22
    Wang, X. N., Haniffa, M. A., Holtick, U., Collin, M. P., Jackson, G., Hilkens, C. M., Holler, E. et al., Regulatory T-cell suppression of CD8+ T-cell-mediated graft-versus-host reaction requires their presence during priming. Transplantation 2009. 88: 188197.
  • 23
    Chappert, P., Leboeuf, M., Rameau, P., Lalfer, M., Desbois, S., Liblau, R. S., Danos, O. et al., Antigen-specific Treg impair CD8(+) T-cell priming by blocking early T-cell expansion. Eur. J. Immunol. 2010. 40: 339350.
  • 24
    Ertelt, J. M., Rowe, J. H., Mysz, M. A., Singh, C., Roychowdhury, M., Aguilera, M. N. andWay, S. S., Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. J. Immunol. 2011. 187: 25692577.
  • 25
    Gonzalez-Rey, E., Chorny, A., Fernandez-Martin, A., Ganea, D. and Delgado, M., Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells. Blood 2006. 107: 36323638.
  • 26
    Stein, P., Weber, M., Prufer, S., Schmid, B., Schmitt, E., Probst, H. C., Waisman, A. et al., Regulatory T cells and IL-10 independently counterregulate cytotoxic T lymphocyte responses induced by transcutaneous immunization. PLoS One 2011. 6: e27911.
  • 27
    Toda, M., Wang, L., Ogura, S., Torii, M., Kurachi, M., Kakimi, K., Nishikawa, H. et al., UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses. Int. J. Cancer 2011. 129: 11261136.
  • 28
    Bots, M., de, B. E., Rademaker-Koot, M. T. and Medema, J. P., Proteinase inhibitor-9 expression is induced by maturation in dendritic cells via p38 MAP kinase. Hum. Immunol. 2007. 68: 959964.