• 1
    Casadevall, A., Evolution of intracellular pathogens. Annu. Rev. Microbiol. 2008. 62: 1933.
  • 2
    Fitzwater, S. P., Watt, J. P., Levine, O. S. and Santosham, M., Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries. Hum. Vaccin. 2010. 6: 810818.
  • 3
    Brandtzaeg, P. and van Deuren, M., Classification and pathogenesis of meningococcal infections. Methods Mol. Biol. 2012. 799: 2135.
  • 4
    Lowy, F. D., Staphylococcus aureus infections. N. Engl. J. Med. 1998. 339: 520532.
  • 5
    Goldschneider, I., Gotschlich, E. C. and Artenstein, M. S., Human immunity to the meningococcus. II. Development of natural immunity. J. Exp. Med. 1969. 129: 13271348.
  • 6
    Tan, L. K., Carlone, G. M. and Borrow, R., Advances in the development of vaccines against Neisseria meningitidis. N. Engl. J. Med. 2010. 362: 15111520.
  • 7
    Kadowaki, N., Antonenko, S., Lau, J. Y. and Liu, Y. J., Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 2000. 192: 219226.
  • 8
    Gilliet, M., Cao, W. and Liu, Y. J., Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 2008. 8: 594606.
  • 9
    Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R. W., Kastelein, R. A., Bazan, F. and Liu, Y. J., Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001. 194: 863869.
  • 10
    Zhang, Z., Kim, T., Bao, M., Facchinetti, V., Jung, S. Y., Ghaffari, A. A., Qin, J. et al., DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity 2011. 34: 866878.
  • 11
    Ito, T., Kanzler, H., Duramad, O., Cao, W. and Liu, Y. J., Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood 2006. 107: 24232431.
  • 12
    Bekeredjian-Ding, I., Schafer, M., Hartmann, E., Pries, R., Parcina, M., Schneider, P., Giese, T. et al., Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology 2009. 128: 439450.
  • 13
    Grouard, G., Rissoan, M. C., Filgueira, L., Durand, I., Banchereau, J. and Liu, Y. J., The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 1997. 185: 11011111.
  • 14
    Hartmann, E., Wollenberg, B., Rothenfusser, S., Wagner, M., Wellisch, D., Mack, B., Giese, T. et al., Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res. 2003. 63: 64786487.
  • 15
    Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R. and Liu, Y. J., Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999. 283: 11831186.
  • 16
    Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S. et al., Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 2012. 484: 514518.
  • 17
    Poth, J. M., Coch, C., Busch, N., Boehm, O., Schlee, M., Janke, M., Zillinger, T. et al., Monocyte-mediated inhibition of TLR9-dependent IFN-alpha induction in plasmacytoid dendritic cells questions bacterial DNA as the active ingredient of bacterial lysates. J. Immunol. 2010. 185: 73677373.
  • 18
    Piccioli, D., Sammicheli, C., Tavarini, S., Nuti, S., Frigimelica, E., Manetti, A. G., Nuccitelli, A. et al., Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation. Blood 2009. 113: 42324239.
  • 19
    Parcina, M., Wendt, C., Goetz, F., Zawatzky, R., Zahringer, U., Heeg, K. and Bekeredjian-Ding, I., Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. J. Immunol. 2008. 181: 38233833.
  • 20
    Veckman, V. and Julkunen, I., Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells. J. Leukoc. Biol. 2008. 83: 296304.
  • 21
    Heyderman, R. S., Davenport, V. and Williams, N. A., Mucosal immunity and optimizing protection with meningococcal serogroup B vaccines. Trends Microbiol. 2006. 14: 120124.
  • 22
    Villwock, A., Schmitt, C., Schielke, S., Frosch, M. and Kurzai, O., Recognition via the class A scavenger receptor modulates cytokine secretion by human dendritic cells after contact with Neisseria meningitidis. Microbes Infect. 2008. 10: 11581165.
  • 23
    Kolb-Maurer, A., Unkmeir, A., Kammerer, U., Hubner, C., Leimbach, T., Stade, A., Kampgen, E. et al., Interaction of Neisseria meningitidis with human dendritic cells. Infect. Immun. 2001. 69: 69126922.
  • 24
    Sisirak, V., Vey, N., Vanbervliet, B., Duhen, T., Puisieux, I., Homey, B., Bowman, E. P. et al., CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues. Blood 2011. 118: 51305140.
  • 25
    Stephens, D. S., Hoffman, L. H. and McGee, Z. A., Interaction of Neisseria meningitidis with human nasopharyngeal mucosa: attachment and entry into columnar epithelial cells. J. Infect. Dis. 1983. 148: 369376.
  • 26
    Pujol, C., Eugene, E., de Saint Martin, L. and Nassif, X., Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells. Infect. Immun. 1997. 65: 48364842.
  • 27
    Sansonetti, P. J. and Medzhitov, R., Learning tolerance while fighting ignorance. Cell 2009. 138: 416420.
  • 28
    Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. A., Coutts, A. G., Pettersson, S. et al., Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 2004. 5: 104112.
  • 29
    Rimoldi, M., Chieppa, M., Larghi, P., Vulcano, M., Allavena, P. and Rescigno, M., Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different. Blood 2005. 106: 28182826.
  • 30
    Tezuka, H., Abe, Y., Asano, J., Sato, T., Liu, J., Iwata, M. and Ohteki, T., Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity 2011. 34: 247257.
  • 31
    Pegtel, D. M., Middeldorp, J. and Thorley-Lawson, D. A., Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers. J. Virol. 2004. 78: 1261312624.