Sculpting MHC class II–restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses
Version of Record online: 5 MAR 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 43, Issue 5, pages 1162–1172, May 2013
How to Cite
Spencer, C. T., Dragovic, S. M., Conant, S. B., Gray, J. J., Zheng, M., Samir, P., Niu, X., Moutaftsi, M., Van Kaer, L., Sette, A., Link, A. J. and Joyce, S. (2013), Sculpting MHC class II–restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur. J. Immunol., 43: 1162–1172. doi: 10.1002/eji.201243087
- Issue online: 25 APR 2013
- Version of Record online: 5 MAR 2013
- Accepted manuscript online: 5 FEB 2013 11:57AM EST
- Manuscript Accepted: 30 JAN 2013
- Manuscript Revised: 2 JAN 2013
- Manuscript Received: 23 OCT 2012
- National Institutes on Minority Health and Health Disparities (NIMHD). Grant Number: G12MD007592
- National Institutes of Health (NIH). Grant Numbers: HL069765, HL054977, AI040079, AI040024, CA068485, DK058404
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Table S1. Sequence and spectral characteristics of the H2Ab-associated peptides eluted from wild type, TAP-/- and ERAAP-/- splenocytes.
Table S2. Nested H2Ab-associated peptides eluted from wild type, TAP-/- and ERAAP-/- splenocytes.
Figure S1. ESI-MS/MS spectra of H2Ab-associated peptides displayed by wild type, TAP-/- and ERAAP-/- splenocytes.
Figure S2. ERAAP- and TAP-deficient MHC class II molecules present longer peptides.
Figure S3. Altered TCR β-chain repertoire of CAP-deficient CD4+ T cells.
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