The evolutionary arms race between NK cells and viruses: Who gets the short end of the stick?

Authors

  • Antonija Miletić,

    1. Department of Histology and Embryology, Faculty of Medicine, Rijeka, Croatia
    2. Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
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  • Astrid Krmpotić,

    1. Department of Histology and Embryology, Faculty of Medicine, Rijeka, Croatia
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  • Stipan Jonjić

    Corresponding author
    1. Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
    • Department of Histology and Embryology, Faculty of Medicine, Rijeka, Croatia
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Full Correspondence: Prof. Stipan Jonjić, Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51 000 Rijeka, Croatia

Fax: +385-51-651-176

e-mail: stipan.jonjic@medri.uniri.hr

Abstract

NK cells are innate lymphocytes that play a key role in the control of various viral infections. Recent studies indicate that NK cells may acquire some features of adaptive immune cells, including the formation of long-lived memory cells. A large and growing body of data indicates that NK cells regulate the adaptive immune response as well. The function and the activation status of NK cells are tightly regulated by signals induced by a broad range of inhibitory and activating cell surface receptors and cytokines released by other immune cells. Here, we review the function of mouse NK-cell receptors involved in virus control and in the regulation of the adaptive immune response. In addition, we discuss viral strategies used to evade NK-cell-mediated control during infection. Finally, the role of several activating Ly49 receptors specific for mouse cytomegalovirus (MCMV), as well as some controversial issues in the field, will be discussed.

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