CCRL2, a fringe member of the atypical chemoattractant receptor family

Authors

  • Annalisa Del Prete,

    1. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
    2. Humanitas Clinical and Research Center, Rozzano, Italy
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  • Raffaella Bonecchi,

    1. Humanitas Clinical and Research Center, Rozzano, Italy
    2. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Rozzano, Italy
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  • Annunciata Vecchi,

    1. Humanitas Clinical and Research Center, Rozzano, Italy
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  • Alberto Mantovani,

    1. Humanitas Clinical and Research Center, Rozzano, Italy
    2. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Rozzano, Italy
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  • Silvano Sozzani

    Corresponding author
    1. Humanitas Clinical and Research Center, Rozzano, Italy
    • Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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Full correspondence: Prof. Silvano Sozzani, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy

Fax: +39-30-371-7747

e-mail: sozzani@med.unibs.it

Abstract

The term atypical chemoattractant receptors is generally used to refer to a subset of G-protein-coupled receptors devoid of chemotactic activity and characterized by the ability to scavenge chemotactic factors from the inflammatory milieu. However, emerging evidence suggests that this class of receptors is heterogeneous in function. In this Viewpoint, we discuss the properties of CCRL2, a molecule devoid of ligand scavenging functions and suggested to regulate leukocyte recruitment by alternative mechanisms.

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