Development of CD27+ marginal zone B cells requires GALT

Authors

  • Venkata A. Yeramilli,

    1. Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA
    Current affiliation:
    1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA
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  • Katherine L. Knight

    Corresponding author
    • Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA
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Full correspondence: Dr. Katherine L. Knight, Department of Microbiology and Immunology, Loyola University Chicago, IL, USA

Fax: +1-708-216-9574

e-mail: kknight@lumc.edu

Abstract

In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27+CD23. In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23+ follicular (FO) B cells and almost no CD27+ MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.

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