Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease
Version of Record online: 21 JUN 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 43, Issue 6, pages 1568–1577, June 2013
How to Cite
Rozot, V., Vigano, S., Mazza-Stalder, J., Idrizi, E., Day, C. L., Perreau, M., Lazor-Blanchet, C., Petruccioli, E., Hanekom, W., Goletti, D., Bart, P.-A., Nicod, L., Pantaleo, G. and Harari, A. (2013), Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease. Eur. J. Immunol., 43: 1568–1577. doi: 10.1002/eji.201243262
- Issue online: 21 JUN 2013
- Version of Record online: 21 JUN 2013
- Accepted manuscript online: 4 MAR 2013 05:15AM EST
- Manuscript Accepted: 26 FEB 2013
- Manuscript Revised: 29 JAN 2013
- Manuscript Received: 17 DEC 2012
- Swiss National Science Foundation
- Swiss vaccine Research Institute
- European Community's Seventh Framework Programme. Grant Numbers: FP7/2007-2013, FP7/2007-2011
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Figure S1. Gating strategies for the flow cytometric analyses.
Figure S2. Representative flow cytometric profiles of LTBI subject and TB patients (A) and cumulative analyses (B) showing IFN-γ, IL-2, and TNF-α expression on Mtb-specific CD8+ T cells.
Figure S3. Frequency (mean ± SEM) of Mtb-specific IFN-γ-producing CD8+ T cells in microbiologically confirmed and clinical PTB subdivided into smear-positive and smear-negative patients.
Figure S4. Proliferation capacity of Mtb-specific CD4+ T-cell responses from the PTB and ETB patients shown in Fig. 4E.
Figure S5. Mtb-specific IFN-γ ELISPOT responses in the 240 subjects with latent Mtb infection.
Table S1. Demographic and clinical description of the 52 TB patients with Mtb-specific CD8+ T-cell responses.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.