Cover Picture: Eur. J. Immunol. 4'13


The cover features a histology image of a lung section from a C57BL/6 mouse intranasally infected with influenza virus. The hematoxylin and eosin-stained section shows substantial cellular influx into airways 6 days after exposure to influenza virus, which is confirmed by flow cytometry to include CD3NKp46+NK1.1+CD127 NK cells. The image is taken from the article by Zhou et al. (pp. 929–938) in which the authors show that NK cells may exacerbate lung pathology during influenza infection in mice. Zhou et al. also show that NK-cellinduced pathology occurs with high-dose, but not low-dose influenza challenge, indicating that with severe influenza infections, NK cells may induce pathology that promote morbidity and mortality.