European Journal of Immunology

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Cover image for Vol. 38 Issue 11

November 2008

Volume 38, Issue 11

Pages 2916–3244

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology
    1. Cover Picture: Eur. J. Immunol. 11/08 (page 2916)

      Jacques Zimmer, Emmanuel Andrès and François Hentges

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200890042

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology
    1. Contents – Eur. J. Immunol. 11/08 (pages 2917–2921)

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200890043

  3. In this Issue

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology
    1. In this issue (pages 2922–2923)

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200890044

  4. News and EFIS

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology
    1. Experimental immunology in Zürich: The legacy of studying disease-related Ag (pages 2924–2926)

      Christian Münz and Burkhard Becher

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200890045

  5. Viewpoints on NK cells

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Preface

      NK cells: New issues and challenges (pages 2927–2929)

      Marco Colonna

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838883

    2. NK cell education: Licensing, arming, disarming, tuning? Which model?

      Tolerance and reactivity of NK cells: Two sides of the same coin? (pages 2930–2933)

      Werner Held

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838755

    3. Beyond licensing and disarming: A quantitative view on NK-cell education (pages 2934–2937)

      Petter Brodin and Petter Höglund

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838760

    4. Cross talk between NK cells and adaptive immune cells

      Killers and beyond: NK-cell-mediated control of immune responses (pages 2938–2942)

      Christopher E. Andoniou, Jérôme D. Coudert and Mariapia A. Degli-Esposti

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838882

    5. NK cells and Treg cells: A fascinating dance cheek to cheek (pages 2942–2945)

      Jacques Zimmer, Emmanuel Andrès and François Hentges

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838813

    6. NK cells in mucosal immunity

      Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues (pages 2946–2948)

      Christian Münz

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838849

    7. Functionally distinct NK-cell subsets: Developmental origins and biological implications (pages 2948–2951)

      James P. Di Santo

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838830

    8. The role of NKG2D in immunoevasion by tumors and viruses

      Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance? (pages 2952–2956)

      Stipan Jonjić, Bojan Polić and Astrid Krmpotić

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838823

    9. Tumor cell recognition by the NK cell activating receptor NKG2D (pages 2957–2961)

      Yenan T. Bryceson and Hans-Gustaf Ljunggren

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838833

    10. Can NK cells be a therapeutic target in human diseases?

      Can NK cells be a therapeutic target in human type 1 diabetes? (pages 2961–2963)

      Francesco Dotta, Cecilia Fondelli and Alberto Falorni

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838851

    11. Can NK cells be a therapeutic target in human diseases? (pages 2964–2968)

      Christopher J. Chan, Daniel M. Andrews and Mark J. Smyth

      Article first published online: 31 OCT 2008 | DOI: 10.1002/eji.200838764

  6. Highlights

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Minireviews

      Allergy therapy: The therapeutic potential of targeting sphingosine kinase signalling in mast cells (pages 2969–2974)

      Alirio J. Melendez

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838642

    2. Commentary

      A two-step model for Langerhans cell migration to skin-draining LN (pages 2975–2980)

      Eduardo J. Villablanca and Jorge R. Mora

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838919

    3. Frontline

      Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells (pages 2981–2992)

      Frank Schmitz, Antje Heit, Stefan Dreher, Katharina Eisenächer, Jörg Mages, Tobias Haas, Anne Krug, Klaus-Peter Janssen, Carsten J. Kirschning and Hermann Wagner

      Article first published online: 15 OCT 2008 | DOI: 10.1002/eji.200838761

  7. Antigen processing

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype (pages 2993–3003)

      Nina Hillen, Gabor Mester, Claudia Lemmel, Andreas O. Weinzierl, Margret Müller, Dorothee Wernet, Jörg Hennenlotter, Arnulf Stenzl, Hans-Georg Rammensee and Stefan Stevanović

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838632

  8. Cellular immune response

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Iγ2b germline transcripts (pages 3004–3014)

      Emeka Igwe, Christian Kosan, Cyrus Khandanpour, Ehssan Sharif-Askari, Bernhard Brüne and Tarik Möröy

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838251

    2. Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function (pages 3015–3027)

      Claudia C. Motran, Karen M. Molinder, Scot D. Liu, Françoise Poirier and M. Carrie Miceli

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838295

    3. Defective B-cell response to T-dependent immunization in lupus-prone mice (pages 3028–3040)

      Haitao Niu, Eric S. Sobel and Laurence Morel

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838417

    4. Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors (pages 3041–3049)

      Jan Kiss, Sirpa Jalkanen, Ferenc Fülöp, Timo Savunen and Marko Salmi

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838651

    5. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis (pages 3050–3059)

      Krista Ouwehand, Saskia J. A. M. Santegoets, Derk P. Bruynzeel, Rik J. Scheper, Tanja D. de Gruijl and Susan Gibbs

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838384

  9. Immunity to infection

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      Nramp1-functionality increases iNOS expression via repression of IL-10 formation (pages 3060–3067)

      Gernot Fritsche, Manfred Nairz, Ernst R. Werner, Howard C. Barton and Günter Weiss

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838449

    2. Evasion of macrophage scavenger receptor A-mediated recognition by pathogenic streptococci (pages 3068–3079)

      Thomas Areschoug, Johan Waldemarsson and Siamon Gordon

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838457

    3. Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis (pages 3080–3089)

      Rosana C. Nascimento, Noeli M. Espíndola, Rafaela A. Castro, Pedro A. C. Teixeira, Carla V. Loureiro y Penha, Leila M. Lopes-Bezerra and Sandro R. Almeida

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838513

    4. Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites (pages 3090–3100)

      Lukasz Kedzierski, Joan M. Curtis, Peter C. Doherty, Emanuela Handman and Katherine Kedzierska

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838423

  10. Immunomodulation

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β (pages 3101–3113)

      Judith S. Satoguina, Tomabu Adjobimey, Kathrin Arndts, Jochen Hoch, Johannes Oldenburg, Laura E. Layland and Achim Hoerauf

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838193

    2. The FGL2-FcγRIIB pathway: A novel mechanism leading to immunosuppression (pages 3114–3126)

      Hao Liu, Itay Shalev, Justin Manuel, Wei He, Elisa Leung, Jennifer Crookshank, Ming F. Liu, Jun Diao, Mark Cattral, David A. Clark, David E. Isenman, Reginald M. Gorczynski, David R. Grant, Li Zhang, Melville J. Phillips, Myron I. Cybulsky and Gary A. Levy

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838338

    3. Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-α responses by pDC (pages 3127–3137)

      Zoe Waibler, Martina Anzaghe, Abdo Konur, Shizuo Akira, Werner Müller and Ulrich Kalinke

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838184

    4. IL-4-mediated fine tuning of IL-12p70 production by human DC (pages 3138–3149)

      Emmanuella Guenova, Thomas Volz, Karin Sauer, Susanne Kaesler, Martin R. Müller, Florian Wölbing, KoMing Chen, Christoph Schwärzler, Peter Brossart, Martin Röcken and Tilo Biedermann

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838463

  11. Innate immunity

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation (pages 3150–3158)

      Yasutaka Okabe, Kohki Kawane and Shigekazu Nagata

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838559

    2. Short Communication

      FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia (pages 3159–3166)

      Daniel M. Schreeder, Jicun Pan, Fu Jun Li, Eric Vivier and Randall S. Davis

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838516

  12. Molecular immunology

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR (pages 3167–3177)

      Gertrude Achatz-Straussberger, Nadja Zaborsky, Sebastian Königsberger, Elke O. Luger, Marinus Lamers, Reto Crameri and Gernot Achatz

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838456

    2. Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions (pages 3178–3190)

      Ying-Chyi Song, Guang-Huan Sun, Tai-Ping Lee, Jason C. Huang, Chia-Li Yu, Chia-Hung Chen, Shye-Jye Tang and Kuang-Hui Sun

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838678

    3. Increased diabetes development and decreased function of CD4+CD25+ Treg in the absence of a functional DAP12 adaptor protein (pages 3191–3199)

      Håkan T. L. Hall, Hanna Sjölin, Hanna Brauner, Elena Tomasello, Marc Dalod, Eric Vivier and Petter Höglund

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838259

  13. Leukocyte signaling

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Research Article

      The role of the PI3K-AKT kinase pathway in T-cell development beyond the β checkpoint (pages 3200–3207)

      Ling Xue, Leslie Chiang, Chulho Kang and Astar Winoto

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838614

    2. The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway (pages 3208–3218)

      Jacob Ngai, Trond Methi, Kjetil Wessel Andressen, Finn Olav Levy, Knut Martin Torgersen, Torkel Vang, Nina Wettschureck and Kjetil Taskén

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838195

  14. Clinical immunology

    1. Top of page
    2. Cover Picture
    3. Contents
    4. In this Issue
    5. News and EFIS
    6. Viewpoints on NK cells
    7. Highlights
    8. Antigen processing
    9. Cellular immune response
    10. Immunity to infection
    11. Immunomodulation
    12. Innate immunity
    13. Molecular immunology
    14. Leukocyte signaling
    15. Clinical immunology

    1. Short Communication

      A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH) (pages 3219–3225)

      Jana Pachlopnik Schmid, Chen-Hsuan Ho, Julien Diana, Gérard Pivert, Agnès Lehuen, Frédéric Geissmann, Alain Fischer and Geneviève de Saint Basile

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838488

    2. Research Article

      B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection (pages 3226–3236)

      Xicheng Wang, Zheng Zhang, Shuye Zhang, Junliang Fu, Jinxia Yao, Yanmei Jiao, Hao Wu and Fu-Sheng Wang

      Article first published online: 16 OCT 2008 | DOI: 10.1002/eji.200838285

    3. Arthritogenic dsRNA is present in synovial fluid from rheumatoid arthritis patients with an erosive disease course (pages 3237–3244)

      Maria Bokarewa, Andrej Tarkowski, Magnus Lind, Leif Dahlberg and Mattias Magnusson

      Article first published online: 7 NOV 2008 | DOI: 10.1002/eji.200838362

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