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Metal-Ion-Mediated Base Pairs in Nucleic Acids

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Abstract

Nucleic acids and their analogues raise more and more interest in research areas outside biology and biochemistry. The functionalization of these evolutionary optimized self-assembling macromolecules with metal ions widens their applicability even further. Previous efforts to incorporate metal ions site-specifically into nucleic acids focused on the covalent attachment of appropriate ligands to either the sugar phosphate backbone or the nucleobases. More recently, the use of metal-ion-mediated base pairs, i.e. the replacement of natural nucleobases by ligands, was suggested as an alternative means. This microreview discusses selected examples of metal-ion-mediated base pairs, including those that comprise unmodified natural nucleobases, and describes possible applications for the resulting metal-modified nucleic acids. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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