Get access

A Dinuclear Gold(I)–Silver(I) Derivative of 2-Cyclopentylidene-2-sulfanylacetic Acid and Related Complexes: Synthesis, Crystal Structures, Properties and Antitumor Activity

Authors

  • Elena Barreiro,

    1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain, Fax: +34-981-547-102
    Search for more papers by this author
  • José S. Casas,

    1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain, Fax: +34-981-547-102
    Search for more papers by this author
  • María D. Couce,

    1. Departamento de Química Inorgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain
    Search for more papers by this author
  • Antonio Laguna,

    1. Departamento de Química Inorgánica, Instituto de Ciencia de Materiales de Aragón, Universidad de Zaragoza – CSIC, 50009 Zaragoza, Spain
    Search for more papers by this author
  • José M. López-de-Luzuriaga,

    1. Departamento de Química, Universidad de La Rioja, Grupo de Síntesis Química de La Rioja, UA-CSIC, Complejo Científico-Tecnológico, 26004 Logroño, Spain
    Search for more papers by this author
  • Miguel Monge,

    1. Departamento de Química, Universidad de La Rioja, Grupo de Síntesis Química de La Rioja, UA-CSIC, Complejo Científico-Tecnológico, 26004 Logroño, Spain
    Search for more papers by this author
  • Agustin Sánchez,

    1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain, Fax: +34-981-547-102
    Search for more papers by this author
  • José Sordo,

    1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain, Fax: +34-981-547-102
    Search for more papers by this author
  • José M. Varela,

    1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain, Fax: +34-981-547-102
    Search for more papers by this author
  • Ezequiel M. Vázquez López

    1. Departamento de Química Inorgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain
    Search for more papers by this author

Abstract

The dinuclear complex [AgAu(PPh3)2cpa] (H2cpa = 2-cyclopentylidene-2-sulfanylacetic acid) was prepared by treating the precursor [Au(PPh3)(Hcpa)] with Ag(PPh3)NO3. The complex was characterised by spectroscopic methods (IR; 1H, 13C, 31P NMR) and mass spectrometry, and the structure was solved by a single-crystal X-ray diffraction study. Luminescence and theoretical studies were carried out, and the antitumor activity was studied in vitro against HeLa-229, A2780 and A2780cis cell lines. The related gold(I)–gold(I), [(AuPPh3)2cpa], and silver(I)–silver(I), [(AgPPh3)2cpa], compounds were also prepared and studied in the solid state and in solution.

Ancillary