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A Highly Selective Fluorescent and Colorimetric Chemosensor for ZnII and Its Application in Cell Imaging



A fluorescent, colorimetric chemosensor, L1, based on 8-aminoquinoline, has been developed as a sensor for Zn2+. L1 exhibited high selectivity and sensitivity towards Zn2+ over other common metal ions in a physiological pH window with a 1:1 binding mode. The ability of L1 to monitor intracellular Zn2+ in living cells has been examined by fluorescence microscopy and indicated that L1 is cell-permeable and biocompatible. We hope that such Zn2+-selective sensors will find application in biomedical and environmental detection.