Full Paper

Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages

  1. Joseph Park1,
  2. Doyeon Bang1,
  3. Eunjung Kim1,
  4. Jaemoon Yang2,
  5. Eun-Kyung Lim1,
  6. Jihye Choi1,
  7. Byunghoon Kang1,
  8. Jin-Suck Suh2,
  9. Hyo Seon Park3,
  10. Yong-Min Huh2,
  11. Seungjoo Haam1

Article first published online: 30 OCT 2012

DOI: 10.1002/ejic.201201026

Issue

European Journal of Inorganic Chemistry

European Journal of Inorganic Chemistry

Volume 2012, Issue 36, pages 5960–5965, December 2012

Additional Information

How to Cite

Park, J., Bang, D., Kim, E., Yang, J., Lim, E.-K., Choi, J., Kang, B., Suh, J.-S., Park, H. S., Huh, Y.-M. and Haam, S. (2012), Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages. Eur. J. Inorg. Chem., 2012: 5960–5965. doi: 10.1002/ejic.201201026

Author Information

  1. 1

    Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea, http://nbsl.yonsei.ac.kr

  2. 2

    Department of Radiology, Yonsei University, Seoul 120-749, Republic of Korea

  3. 3

    Department of Architectural Engineering, Yonsei University, Seoul 120–749, South Korea

Publication History

  1. Issue published online: 10 DEC 2012
  2. Article first published online: 30 OCT 2012
  3. Manuscript Received: 6 SEP 2012

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Keywords:

  • Nanomaterials;
  • Nanoparticles;
  • Imaging agents;
  • Magnetic resonance imaging;
  • Ligand effects;
  • Manganese

Abstract

Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages.

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