Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives – Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies

Authors

  • Telma F. S. Silva,

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
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  • Piotr Smoleński,

    1. Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383 Wrocław, Poland
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  • Luísa M. D. R. S. Martins,

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
    2. Area Departamental de Engenharia Química, ISEL, R. Conselheiro Emídio Navarro, 1959-007 Lisbon, Portugal
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  • M. Fátima C. Guedes da Silva,

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
    2. Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Campo Grande 376, 1749-024 Lisbon, Portugal
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  • Alexandra R. Fernandes,

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
    2. Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Campo Grande 376, 1749-024 Lisbon, Portugal
    3. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologias, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
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  • Daniel Luis,

    1. Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Campo Grande 376, 1749-024 Lisbon, Portugal
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  • Ana Silva,

    1. Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Campo Grande 376, 1749-024 Lisbon, Portugal
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  • Susana Santos,

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
    2. Universidade Lusófona de Humanidades e Tecnologias, ULHT Lisbon, Campo Grande 376, 1749-024 Lisbon, Portugal
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  • Pedro M. Borralho,

    1. Research Institute for Medicine and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal
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  • Cecília M. P. Rodrigues,

    1. Research Institute for Medicine and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal
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  • Armando J. L. Pombeiro

    1. Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Technical University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
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Abstract

The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)2][BF4] (2, DION = 1,10-phenanthroline-5,6-dione), [Zn(DION)2]Cl2 (3) and [ZnCl(κO-PTA=O)(DION)][BF4] (4) were synthesized by reaction of CoCl2 with [mPTA]I or DION and ZnCl2 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far-IR, 1H, 13C and 31P{1H} NMR spectroscopy, ESI-MS, elemental analyses and single-crystal X-ray diffraction structural analysis (for 1). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.

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