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Keywords:

  • Palladium;
  • Phosphanes;
  • DNA;
  • Heterometallic complexes;
  • Thiopurines

Abstract

The new water-soluble palladium(II) complexes Na2{trans-[PdCl2(mTPPMS-κP)2]} (1), (CN4H7)Na{trans-[PdCl2(mTPPMS-κP)2]} (2) and the 2D polymer trans-{Pd-μ-[mTPPMS-1κP:2κO-Na1/2(H2O)]-μ-[mTPPMS-1κP:2κO′-Na′1/2(H2O)]-μ-[8TTH-1κS:2κO6Na1/2(H2O)]-μ-[8TTH-1κS:2κO6-Na′1/2(H2O)]}n (3) {mTPPMS = Ph2P[3-OS(O)2C6H4]; 8-TTH = 8-thiotheophyllinate} have been synthesized and characterised by NMR and IR spectroscopy as well as elemental analysis. The crystal structures of 2 and 3 were determined by X-ray diffraction. The binding properties of the new hydrosoluble palladium complexes towards DNA were studied by the mobility shift assay, which showed that complex 1 is more active than cisplatin towards DNA.