A Modular Approach towards the Synthesis of Target-Specific MRI Contrast Agents (pages 3577–3585)
Peter Verwilst, Svetlana V. Eliseeva, Sophie Carron, Luce Vander Elst, Carmen Burtea, Geert Dehaen, Sophie Laurent, Koen Binnemans, Robert N. Muller, Tatjana N. Parac-Vogt and Wim M. De Borggraeve
Version of Record online: 15 JUL 2011 | DOI: 10.1002/ejic.201100575
A modular pathway for the synthesis of new specific MRI contrast agents and their luminescent analogues is described. By using two azide-bearing probes, a “click” reaction with an alkyne-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) analogue yielded a possible blood-pool contrast agent, as well as a contrast agent with a high affinity for cells expressing αvβ3 integrin.