Synthesis and Stereoselective Interconversion of Chiral 1-Aza-3,6-diphosphacycloheptanes (pages 1857–1866)
Elvira I. Musina, Andrey A. Karasik, Anna S. Balueva, Igor D. Strelnik, Tatiana I. Fesenko, Alexey B. Dobrynin, Tatiana P. Gerasimova, Sergey A. Katsyuba, Olga N. Kataeva, Peter Lönnecke, Evamarie Hey-Hawkins and Oleg G. Sinyashin
Article first published online: 22 FEB 2012 | DOI: 10.1002/ejic.201101337
1-Aza-3,6-diphosphacycloheptanes with chiral substituents on the nitrogen atoms were synthesized with the prevailing formation of meso stereoisomers (PRPS), which can form P,P-chelate platinum(II) complexes. In solution, the selective stereoconversion of the pure meso isomers into a mixture of PRPRCS(R) and PSPSCS(R) isomers was observed. Kinetic and DFT studies of this process were performed.