Effect of the Metal Ion on the anti T. cruzi Activity and Mechanism of Action of 5-Nitrofuryl-Containing Thiosemicarbazone Metal Complexes (pages 4677–4689)
Micaella Cipriani, Jeannette Toloza, Lara Bradford, Eugenia Putzu, Marisol Vieites, Estela Curbelo, Ana Isabel Tomaz, Beatriz Garat, Juan Guerrero, Jorge S. Gancheff, Juan Diego Maya, Claudio Olea Azar, Dinorah Gambino and Lucía Otero
Article first published online: 8 SEP 2014 | DOI: 10.1002/ejic.201402614
Eight complexes of formula [MCl(L)(PTA)] (M = Pd or Pt, L = 5-nitrofuryl-containing thiosemicarbazone ligands, PTA = 1,3,5-triaza-7-phosphaadamantane) were obtained. Most were active in vitro against T. cruzi. The mechanism involves bioreduction and formation of free radical species. All interact with DNA in an intercalative-like manner, but this does not lead to their antichagasic activity.