Glycoconjugated Rhenium(I) and 99m-Technetium(I) Carbonyl Complexes from Pyridyltriazole Ligands Obtained by “Click Chemistry” (pages 6290–6297)
Justyna A. Czaplewska, Frank Theil, Esra Altuntas, Tobias Niksch, Martin Freesmeyer, Bobby Happ, David Pretzel, Hendrik Schäfer, Makoto Obata, Shigenobu Yano, Ulrich S. Schubert and Michael Gottschaldt
Article first published online: 25 NOV 2014 | DOI: 10.1002/ejic.201402881
A series of pyridyltriazole ligands containing sugar moieties and their corresponding Re(I) complexes were synthesized and characterized. Stability tests against histidine showed that the complexes are stable up to 2.5 h; the 99mTc-labeled complex was stable up to 24 h. All sugar-based ReI complexes were nontoxic against HepG2 cells; in contrast, the ReI complex without a carbohydrate moiety was toxic.