Iridium(III) Complexes of Terpyridine- and Terpyridine-Analogous Ligands Bearing Sugar Residues and Their in vitro Activity (pages 3480–3488)
Aram Prokop, Justyna A. Czaplewska, Mara Clausen, Marcel König, Andreas Wild, Rico Thorwirth, Benjamin Schulze, Krzysztof Babiuch, David Pretzel, Ulrich S. Schubert and Michael Gottschaldt
Version of Record online: 22 JUN 2016 | DOI: 10.1002/ejic.201600325
A series of terpyridine and terpyridine-analogous ligands bearing sugar moieties attached by different glycosidic bonds and their IrIII complexes was synthesized and characterized. Studies on cell viability, selectivity, drug resistance in vitro, and the apoptosis mechanism were performed. The results revealed enhanced activity of a complex bearing acetylated thioglucose.