This review is based on a presentation given in 93rd AOCS Annual Meeting & Expo, Montreal, Quebec, Canada 2002
Platelet activating factor — a molecular link between atherosclerosis theories†
Article first published online: 6 NOV 2003
Copyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Lipid Science and Technology
Volume 105, Issue 11, pages 705–716, November 2003
How to Cite
Demopoulos, C. A., Karantonis, H. C. and Antonopoulou, S. (2003), Platelet activating factor — a molecular link between atherosclerosis theories. Eur. J. Lipid Sci. Technol., 105: 705–716. doi: 10.1002/ejlt.200300845
- Issue published online: 6 NOV 2003
- Article first published online: 6 NOV 2003
- Manuscript Accepted: 10 SEP 2003
- Manuscript Received: 21 MAY 2003
- platelet-activating factor;
- PAF-like lipids;
The most common causes of death in westernized societies remain heart disease and stroke. For this reason the prevention of atherosclerosis is a major objective of modern medicine. Platelet-Activating Factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a crucial mediator in the inflammatory response. PAF is synthesized by several types of cells, including platelets, monocytes, macrophages, foam cells and endothelial cells upon activation. Many experimental data reveal that atherogenic activities of oxidized LDLs can be attributed to PAF and PAF-like lipids, which render these molecules the initiators of atherosclerosis.
Several theories have been formulated for atherosclerosis. The purpose of this review is to highlight the significance of PAF and PAF-like lipids during the early stages of atherosclerosis. Secondly to link the biological action of PAF molecules to the most accepted, current hypotheses of atherosclerosis. Thirdly to propose a mechanism for the initiation and propagation of atherosclerosis by PAF.
The mechanism we propose offers a new biochemical approach and may help to explains the beneficial effects of the Mediterranean diet. Mediterranean foods contain a significant number of lipid-like components with anti-PAF action in vitro. The comsumption of PAF antagonist from Mediterranian foods inhibits the development of atherosclerosis. Such observations suggest that our hypothesis serves as a sound basis for further research.