Effect of Lactobacillus plantarum P-8 on lipid metabolism in hyperlipidemic rat model

Authors

  • Yan Bao,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
    2. Public Health College, Medical College of Baotou, Baotou, P. R. China
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  • Zhanli Wang,

    1. The First Affiliated Hospital, Medical College of Baotou, Baotou, P. R. China
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  • Yong Zhang,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Jiachao Zhang,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Lifeng Wang,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Ximei Dong,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Fang Su,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Guoqiang Yao,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Shuiquan Wang,

    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
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  • Heping Zhang

    Corresponding author
    1. The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
    • The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot 010018, P. R. China Fax: +86 471 4305357
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Abstract

Probiotics have been reported to play an important role in the prevention of metabolic disorders. We recently identified a novel probiotic strain Lactobacillus plantarum (L. plantarum) P-8. The objective of this study was to determine the effects of L. plantarum P-8 on lipid metabolism of rats fed with high fat diet. All experimental rats were divided into three groups: control group, model group, and L. plantarum P-8 group. Changes in serum lipid levels, hepatic lipid deposition, serum oxidative stress-related parameters, activities of liver function marker enzymes, organ indices, gut microflora, and fecal lipids were assessed. Compared with model group, L. plantarum P-8 exhibited hypolipidemic effects by lowering serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol levels, accompanied with elevation of high-density lipoprotein cholesterol level. L. plantarum P-8 also exerted beneficial effects against high-fat diet-induced oxidative stress, curtailed the accumulation of liver lipids and protected healthy liver function. Moreover, L. plantarum P-8 was able to regulate intestinal bacteria and enhance the fecal excretion of TC, TG, and bile acid. These findings indicate that L. plantarum P-8 may represent a potential therapeutic agent for controlling hyperlipidemia.

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