SEARCH

SEARCH BY CITATION

Special topic: Lipid (nano)particles for drug delivery

  1. Top of page
  2. Special topic: Lipid (nano)particles for drug delivery
  3. Eggplant enzyme degrades valuable antioxidants of olive oil
  4. 3-MCPD determination: Improved accuracy

Encapsulation of drugs in lipid particles provides several advantages over conventional formulations including controlled release, targeted delivery, reduced adverse effects, longer circulation, improved bioavailability and stability. Kontogiannopoulos et al. [1113–1123] prepared shikonin-loaded phosphatidylcholine liposomes. Shikonin, a natural hydroxynap hthoquinone with wound healing, antimicrobial, anti-inflammatory and antioxidant properties, appears to be effective against certain types of tumors. The liposomes inhibited tumor growth in human breast, glioma, and non-small cell lung cancer cell lines. Ma et al. [1106–1112] used anionic long circulating liposomes to deliver radioiodinated bcl-2 antisense oligonuc leotides to mammary tumors in rats. As a consequence of the combined irradiation and antisense effects, the tumor growth was suppressed, expression of the apoptosis regulator Bcl-2 decreased, and increased tumour cell necrosis was observed. Weng et al. [1095–1105] studied in vitro degradation kinetics and in vivo pharmacokinetics of bufadienolides—com ponents of toad venom—loaded in lipid microspheres after intravenous, intraportal, intraduodenal, and intragastric administration to rats. The microspheres protected the drug from degradation in the plasma and gastrointestinal tract and improved its performance compared to bufadienolides formulated in a solution.

Kontogiannopoulos, K.N. et al. Shikonin-loaded liposomes as a new drug delivery system: Physicochemical characterization and in vitro cytotoxicity. Eur. J. Lipid Sci. Technol. 2011, 113, 1113–1123.

Ma, C. et al. Delivery of radioiodinated antisense oligonucleotides in long circulating liposomes in vivo. Eur. J. Lipid Sci. Technol. 2011, 113, 1106–1112.

Weng, Y. et al. Bioavailability and pharmacokinetics of bufadienolides-loaded lipid microspheres after different administrations to rats. Eur. J. Lipid Sci. Technol. 2011, 113, 1095–1105.

Thumbnail image of

Eggplant enzyme degrades valuable antioxidants of olive oil

  1. Top of page
  2. Special topic: Lipid (nano)particles for drug delivery
  3. Eggplant enzyme degrades valuable antioxidants of olive oil
  4. 3-MCPD determination: Improved accuracy

De Leonardis et al. [1124–1131] demonstrate that polyphenol oxidase present in eggplant is responsible for a depletion of o-diphenols from olive oil when eggplant is preserved in extra virgin olive oil. Consequently, the oxidative stability of the oil is compromised and the oil can become rancid quickly. Residual polyphenol oxidase activity, which may also be present in other vegetables, needs to be considered when vegetables are preserved in olive oil.

De Leonardis, A. et al. Polyphenol oxidase from eggplant reduces the content of phenols and oxidative stability of olive oil. Eur. J. Lipid Sci. Technol. 2011, 113, 1124–1131.

Thumbnail image of

3-MCPD determination: Improved accuracy

  1. Top of page
  2. Special topic: Lipid (nano)particles for drug delivery
  3. Eggplant enzyme degrades valuable antioxidants of olive oil
  4. 3-MCPD determination: Improved accuracy

Accurate determination of the carcinogen 3-monochloropropane-1,2-diol using the standard Deutsche Gesellschaft für Fettwissenschaft method C-III 18 is difficult at low concentrations due to the low recovery of 3-MCPD derivatives from the aqueous phase into the organic phase during extraction. Kaze et al [1168–1171] report that substituting n-hexane with n-butanol, chloroform, or ethyl acetate increases the recovery and thus this simple modification improves the accuracy of the method, especially at concentrations below 1 ppm 3-MCPD.

Kaze, N. et al. Improvement of accuracy in quantification of 3-monochloropropane-1,2-diol esters by Deutsche Gesellschaft für Fettwissenschaft standard methods C-III 18. Eur. J. Lipid Sci. Technol. 2011, 113, 1168–1171.

Thumbnail image of