Short Communication

Association of total cholesterol/apoB100 with lipid and protein oxidation products in stable angina patients treated with statins

  1. Pawel Burchardt1,*,
  2. Piotr Tabaczewski2,
  3. Tomasz Synowiec3,
  4. Dawid Murawa4,
  5. Jakub Żurawski2,
  6. Adam Szczepanik1,
  7. Agnieszka Banaszak1,
  8. Anna Pałasz1,
  9. Henryk Wysocki1

Article first published online: 18 OCT 2012

DOI: 10.1002/ejlt.201200107

Issue

European Journal of Lipid Science and Technology

European Journal of Lipid Science and Technology

Volume 114, Issue 12, pages 1335–1339, December 2012

Additional Information

How to Cite

Burchardt, P., Tabaczewski, P., Synowiec, T., Murawa, D., Żurawski, J., Szczepanik, A., Banaszak, A., Pałasz, A. and Wysocki, H. (2012), Association of total cholesterol/apoB100 with lipid and protein oxidation products in stable angina patients treated with statins. Eur. J. Lipid Sci. Technol., 114: 1335–1339. doi: 10.1002/ejlt.201200107

Author Information

  1. 1

    Division of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Poland

  2. 2

    Department of Biology and Environmental Sciences, Poznan University of Medical Sciences, Poland

  3. 3

    Department of General and Vascular Surgery and Angiology, Poznan University of Medical Sciences, Poland

  4. 4

    1st Department of Surgical Oncology and General Surgery, Wielkopolska Cancer Center, Poznan, Poland

*Division of Cardiology-Intensive Therapy, Poznan University of Medical Sciences ul. Przybyszewskiego 49, 60-355 Poznan, Poland Fax: +4861 869-16-89

Publication History

  1. Issue published online: 11 DEC 2012
  2. Article first published online: 18 OCT 2012
  3. Accepted manuscript online: 3 SEP 2012 02:30AM EST
  4. Manuscript Accepted: 16 AUG 2012
  5. Manuscript Revised: 25 JUL 2012
  6. Manuscript Received: 12 MAR 2012

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Keywords:

  • apoB100;
  • Coronary artery disease;
  • LDL;
  • Total cholesterol

Abstract

Oxidative modification of lipids contained in lipoproteins may contribute to initiation of local inflammation in the vascular endothelium and ultimately to the atherosclerotic plaque formation. Therefore, in patients with high cardiovascular risk in primary as well as in secondary prevention, it is recommended that the serum low-density lipoprotein (LDL) cholesterol be reduced. However, the management of patients with LDL level at goal is still a matter of debate. Various parameters have been proposed for predicting increased cardiovascular risk. It was found that among known indicators of lipid metabolism deregulation the ratio of total cholesterol/apoB100 associates with the severity of coronary arteriosclerosis in population of individuals with LDL levels < 100 mg/dL. There are several possible hypotheses for this phenomenon (impaired reduction of apoB100 expression by statins or increased triglyceride content of apoB100 containing lipoproteins compatible with oxidized LDL phenotype in subjects with high cardiovascular burden). In this paper, we discuss the increased susceptibility of plasma lipoproteins to oxidation. To verify this hypothesis, we undertook to determine, in the susceptible population described previously, whether there is a relation of total cholesterol (TC) ratio to apoB100 with known oxidative stress exponents such as protein and lipid oxidation products (LPP). TC/apoB100 was found to have a significant association with the level of LPPs in most examined subgroups (except subjects on statins with LDL > 100 mg/dL).

See commentary by Grabowski http://dx.doi.org/10.1002/ejlt.201200295

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