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Keywords:

  • Insulin resistance;
  • Polyunsaturated fatty acids

Abstract

Consumption of polyunsaturated fatty acids (PUFAs) has been shown to be beneficial in the restoration of insulin sensitivity. It has become clear that n-3 and n-6 PUFAs act at the nuclear level to affect expression of genes involved in metabolic pathways. PUFAs act via transcription factors such as PPARs and sterol-regulatory-element-binding proteins (SREBPs) to affect transcription of genes involved in lipogenesis and fatty acid oxidation.