Get access

Modulation of insulin resistance by PUFA in metabolic tissues

Authors

  • Martin Kopál,

    1. Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Search for more papers by this author
  • Jana Muchová,

    Corresponding author
    • Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Search for more papers by this author
  • Zdeňka Ďuračková

    1. Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Search for more papers by this author

Correspondence: Jana Muchová, Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia

E-mail: jana.muchova@fmed.uniba.sk

Fax: +421 59357 557

Abstract

Consumption of polyunsaturated fatty acids (PUFAs) has been shown to be beneficial in the restoration of insulin sensitivity. It has become clear that n-3 and n-6 PUFAs act at the nuclear level to affect expression of genes involved in metabolic pathways. PUFAs act via transcription factors such as PPARs and sterol-regulatory-element-binding proteins (SREBPs) to affect transcription of genes involved in lipogenesis and fatty acid oxidation.

Ancillary