Eur. J. Lipid Sci. Technol. 7∕2013

Homogeneous metal complex catalyzes conjugation of methyl linoleate

Conjugated linoleic acids are interesting both in nutrition and in chemical synthesis: they have many health benefits and are important polymer building blocks. Because natural resources are limited, efficient production processes are needed. Behr et al. describe the conjugation of linoleate methyl ester with homogeneous transition metal catalysts under low temperatures and at short reaction times. The best results were obtained with the Wilkinson-catalyst in combination with a Lewis-acid promoter tin(II)chloride-dihydrate.

Behr, A. et al. Homogeneous metal complex catalyzed conjugation of methyl linoleate. Eur. J. Lipid Sci. Technol. 2013, 115, 721–728.

Philippaerts, A. et al. Conjugated linoleic acids and conjugated vegetable oils: From nutraceutical to bio-polymer. Eur. J. Lipid Sci. Technol. 2013, 115, 717–720.


Can phosphatidylserine prevent UV-induced skin aging?

Lee at al. evaluated the protective effects of phosphatidylserine on ultraviolet radiation-induced photoaging in human dermal fibroplasts (HDF). Phosphatidylserine increased type I procollagen synthesis and decreased the activity of matrix metalloproteinase-1 (MMP-1, also known as fibroblast collagenase), an enzyme which is involved in the breakdown of interstitial collagens. The inhibition of MMP-1 occurs by downregulating the MAPK∕AP-1 signaling pathway in UVB-induced HDF. These results suggest that PS could potentially be used as a therapeutic agent for the treatment and prevention of photoaging and possibly even natural aging in human skin.

Lee, S-H. et al., Protective effect and mechanism of phosphatidylserinein UVB-induced human dermal fibroblasts. Eur. J. Lipid Sci. Technol. 2013, 115, 783–790.


Toxic effects of triacylglycerol polymers on macrophages

Triacylglycerols may form polar oxidized triglyceride polymers (TGP) by oxidization during storage, refining, cooking, and especially high-temperature frying. Cao and colleagues show that TGP is toxic in macrophages – the exposure to TGP resulted in a lower viability of the cells, decreased phagocytic activity, increased levels of reactive oxygen species and increased lactate dehydrogenase levels. The authors propose that the concentration of TGP could be employed as a quality control index for cooking oils.

Cao, W. et al., Toxic effects of triacylglycerol polymer on macrophages in vitro. Eur. J. Lipid Sci. Technol. 2013, 115, 756–763.