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Cytotoxic complexes fatty acid/α-lactalbumin

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  2. Cytotoxic complexes fatty acid/α-lactalbumin
  3. New biobased carboxylic acid hardeners for epoxy resins
  4. C18-unsaturated branched-chain FA isomers

Complexes of the milk protein α-lactalbumin and oleic acid have previously been shown to be cytotoxic. Here complexes with vaccenic, linoleic, palmitoleic, stearic, and elaidic acid were prepared and compared to oleic acid. The cytotoxicity to human promyelocytic leukemia-derived cells of all the variants was similar to that previously determined for α-lactalbumin/oleic acid complexes, and the amount of fatty acid per α-lactalbumin molecule was found to correlate with the cytotoxicity. Such complexes, called HAMLET or BAMLET (human/bovine alpha lactalbumin made lethal to tumor cells), hold promise for the treatment of certain tumors.

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Brinkmann, C. R. et al. The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid. Eur. J. Lipid Sci. Technol. 2013, 115, 591–600.

New biobased carboxylic acid hardeners for epoxy resins

  1. Top of page
  2. Cytotoxic complexes fatty acid/α-lactalbumin
  3. New biobased carboxylic acid hardeners for epoxy resins
  4. C18-unsaturated branched-chain FA isomers

In this paper, Jaillet et al. report the modification of soybean oil into a novel biobased polyacid hardener by thiol-ene coupling with thioglycolic acid. The produced polyacids provide biobased building blocks for further epoxy resin syntheses via epoxy groups reactions. The obtained epoxy resins are partially biobased and may be applied as binders and coatings.

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Jaillet, F., et al. New biobased carboxylic acid hardeners for epoxy resins. Eur. J. Lipid Sci. Technol. 2013, 115, 698–708.

C18-unsaturated branched-chain FA isomers

  1. Top of page
  2. Cytotoxic complexes fatty acid/α-lactalbumin
  3. New biobased carboxylic acid hardeners for epoxy resins
  4. C18-unsaturated branched-chain FA isomers

Iso-oleic acid is a mixture of C18-unsaturated branched-chain fatty acid isomers with a methyl group on various positions of the alkyl chain. This paper focuses on determining whether the branched-chain materials produced by the solid acid catalyzed skeletal isomerization of moderately pure oleic acid are good candidates for the lubricant industry. Their low temperature properties, thermo-oxidative stability under extreme conditions, and lubricity were examined, and the material was analyzed by GC × GC/TOF-MS. Iso-oleic acid and methyl iso-oleate have excellent cold flow and lubricity properties, showing excellent potential in replacing petroleum-based lubricants.

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Ngo, H. L. et al. C18-unsaturated branched-chain fatty acid isomers: Characterization and physical properties. Eur. J. Lipid Sci. Technol. 2013, 115, 676–683.