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Asymmetric Electrophilic α-Amination of Carbonyl Groups

Authors

  • Christine Greck,

    1. Laboratoire S.I.R.C.O.B., UMR CNRS 8086; Université de Versailles Saint-Quentin-en-Yvelines 45, avenue des Etats Unis; 78035 Versailles cédex; France, Fax: (internat.) +33-1-39254452
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  • Bruno Drouillat,

    1. Laboratoire S.I.R.C.O.B., UMR CNRS 8086; Université de Versailles Saint-Quentin-en-Yvelines 45, avenue des Etats Unis; 78035 Versailles cédex; France, Fax: (internat.) +33-1-39254452
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  • Christine Thomassigny

    1. Laboratoire S.I.R.C.O.B., UMR CNRS 8086; Université de Versailles Saint-Quentin-en-Yvelines 45, avenue des Etats Unis; 78035 Versailles cédex; France, Fax: (internat.) +33-1-39254452
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Abstract

The electrophilic amination constitutes an unconventional C−N bond-forming reaction. Asymmetric versions have been developed using chiral reagents or catalysts and starting from optically pure substrates. The aminated products can be obtained with high stereoselectivities. These methodologies are flexible routes for the synthesis of α-amino acids and nitrogen heterocycles. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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