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Microreview
Recent Advances in the Mitsunobu Reaction: Modified Reagents and the Quest for Chromatography-Free Separation
Article first published online: 26 MAY 2004
DOI: 10.1002/ejoc.200400003
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Dembinski, R. (2004), Recent Advances in the Mitsunobu Reaction: Modified Reagents and the Quest for Chromatography-Free Separation. Eur. J. Org. Chem., 2004: 2763–2772. doi: 10.1002/ejoc.200400003
Publication History
- Issue published online: 15 JUN 2004
- Article first published online: 26 MAY 2004
- Manuscript Received: 3 JAN 2004
- Abstract
- Article
- References
- Cited By
Keywords:
- Mitsunobu reaction;
- Fluorous compounds;
- Phosphanes;
- Azo compounds;
- Phase switching
Abstract
Recent progress in synthetic approaches to the Mitsunobu reaction are reviewed. Efforts that have focused on the phase-switching modifications of phosphane, azodicarboxylate, and nucleophilic components are emphasized. An approach to product separation with fluorous compounds is reviewed in detail. Alternative reagents and recently introduced products are cited. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)