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Acetonyltriphenylphosphonium Bromide (ATPB): A Versatile Reagent for the Acylation of Alcohols, Phenols, Thiols and Amines and for 1,1-Diacylation of Aldehydes under Solvent-Free Conditions
Article first published online: 20 JUN 2005
DOI: 10.1002/ejoc.200500066
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Khan, A. T., Choudhury, L. H. and Ghosh, S. (2005), Acetonyltriphenylphosphonium Bromide (ATPB): A Versatile Reagent for the Acylation of Alcohols, Phenols, Thiols and Amines and for 1,1-Diacylation of Aldehydes under Solvent-Free Conditions. European Journal of Organic Chemistry, 2005: 2782–2787. doi: 10.1002/ejoc.200500066
Publication History
- Issue published online: 20 JUN 2005
- Article first published online: 20 JUN 2005
- Manuscript Received: 27 JAN 2005
- Abstract
- Article
- References
- Cited By
Keywords:
- Acylations;
- Alcohols;
- Phenols;
- Amines;
- Thiols;
- Acetonyltriphenylphosphonium bromide
Graphical Abstract
Abstract
A wide variety of alcohols, phenols, amines and thiols may easily be converted into the corresponding acetate derivatives by treatment with acetic anhydride (1.5–2.0 equivalents) in the presence of acetonyltriphenylphosphonium bromide (ATPB; 5 mol %) in good yields at room temperature. With the same precatalyst, both aliphatic and aromatic aldehydes can also be transformed into the corresponding gem-diacetates under reflux conditions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)