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Palladium-Catalyzed Coupling Reactions for the Functionalization of BODIPY Dyes with Fluorescence Spanning the Visible Spectrum



The BODIPY fluorophore can easily be functionalized at the 3- (and 5-)position(s) with one or two aryl, ethenylaryl and ethynylaryl moieties by palladium-catalyzed coupling reactions of the 3,5-dichloroBODIPY derivative using the Stille, Suzuki, Heck and Sonogashira reactions. The fluorescence excitation and emission spectral maxima of the novel BODIPY derivatives range from green to near-infrared. The new class of ethynylaryl-substituted BODIPY dyes are extremely bright fluorescent compounds.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)