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Keywords:

  • 1,4-Conjugate addition;
  • Michael addition;
  • Asymmetric reactions;
  • Chiral amines;
  • Multicomponent reactions;
  • Organocatalysis

Abstract

Recent progress in the field of asymmetric organocatalytic 1,4-conjugate addition reactions, regarded as belonging among the more synthetically important carbon–carbon bond-forming reactions, is described. The focus is on some recent advances in the following selected reactions: additions of various nucleophiles to α,β-unsaturated cyclic and acyclic enals, enones, vinyl sulfones and nitro olefins, addition of malonates and/or ketones to acyclic enones, or of aldehydes and ketones to vinyl ketones and nitro olefins, together with some multicomponent domino reactions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)