Procedures for and Possible Mechanisms of Pd-Catalyzed Allylations of Primary and Secondary Amines with Allylic Alcohols



This review describes the different Pd-catalyzed methods that afford allylic amines from intermolecular reactions between allylic alcohols and amines and, with personal comments, the mechanisms that have been proposed. Allylic amines are an important class of compounds, while a wide structural variety of allylic alcohols are commercially available and are abundant in nature. The advantages of the use of allylic alcohols over that of their derivatives such as allylic esters or carbonates are the high atom efficiency and the formation only of water as the by-product. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)