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Microreview
Peptidomimetics, Glycomimetics and Scaffolds from Carbohydrate Building Blocks
Article first published online: 25 JUN 2007
DOI: 10.1002/ejoc.200700248
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Murphy, P. V. (2007), Peptidomimetics, Glycomimetics and Scaffolds from Carbohydrate Building Blocks. Eur. J. Org. Chem., 2007: 4177–4187. doi: 10.1002/ejoc.200700248
Publication History
- Issue published online: 10 AUG 2007
- Article first published online: 25 JUN 2007
- Manuscript Received: 20 MAR 2007
Funded by
- SFI, Astellas USA Foundation
- Irish Research Council for Science, Engineering and Technology (IRCSET)
- the European Commission (MC-EIF)
- Enterprise Ireland and the Programme for Research in Third Level Institutions Cycle 3, administered by the HEA
- Abstract
- Article
- References
- Cited By
Keywords:
- Peptidomimetics;
- Macrocyclic scaffolds;
- Hybrid compounds;
- Multivalent ligands;
- Drug discovery
Abstract
Saccharides, due to their high density of functional groups and availability as chiral building blocks are scaffolds for bioactive compound discovery. Pyranosides and iminosugar-based peptidomimetics have been synthesised as ligands for somatostatin receptors and HIV protease. The synthesis of polyhydroxylated macrolides related to natural products and cyclophanes has been achieved from carbohydrate fragments with a view to investigation of their potential as scaffolds. In addition, the trajectory of aromatic systems grafted to saccharides have been studied and this has led to the synthesis of probes for the study of carbohydrate protein interactions. These compounds include geometrically diverse bivalent glycomimetics derived from scaffolds that are hybrids of sugars and aromatic groups. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)