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Asymmetric Catalytic Intramolecular Pauson–Khand Reactions with Ir(phox) Catalysts†

  1. Zhong-Lin Lu,
  2. Eva Neumann,
  3. Andreas Pfaltz

Article first published online: 25 MAY 2007

DOI: 10.1002/ejoc.200700330

Issue

European Journal of Organic Chemistry

European Journal of Organic Chemistry

Volume 2007, Issue 25, pages 4189–4192, September 2007

Additional Information

How to Cite

Lu, Z.-L., Neumann, E. and Pfaltz, A. (2007), Asymmetric Catalytic Intramolecular Pauson–Khand Reactions with Ir(phox) Catalysts. Eur. J. Org. Chem., 2007: 4189–4192. doi: 10.1002/ejoc.200700330

Author Information

  1. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland, Fax: +41-61-2671103

  1. †

    Dedicated to Professor Miguel Yus on the occasion of his 60th birthday

Publication History

  1. Issue published online: 10 AUG 2007
  2. Article first published online: 25 MAY 2007
  3. Manuscript Received: 26 APR 2007

Funded by

  • Swiss National Science Foundation

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Keywords:

  • Pauson–Khand reactions;
  • Asymmetric catalysis;
  • N,P ligands;
  • Phosphane–oxazolines;
  • Iridium

Abstract

Iridium complexes derived from chiral phosphane–oxazolines (phox ligands) are efficient catalysts for intramolecular Pauson–Khand reactions. Under optimized conditions high yields and enantioselectivities of > 90 % ee were obtained with 2 mol-% of catalyst. The influence of the CO pressure and the anion were studied. The structure of a dicarbonyl(phox)iridium complex was determined by X-ray analysis.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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