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Keywords:

  • Amino acids;
  • Tandem reactions;
  • Metathesis;
  • Heterocycles;
  • Macrocycles;
  • Ring-closing metathesis

Abstract

Suitably functionalized glycine derivatives undergo a cross-enyne and ring-closing metathesis cascade to generate macroheterocyclic ring systems in good yield. These macrocycles, prepared on the basis of a fragment coupling strategy, consist of 13–16-membered rings. To this end, 1,5-hexadiene was found to be a promising cross-coupling partner to generate macrocycles by this tandem metathesis sequence.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)