Intermolecular Hydrogen-Bonding Pattern of a Glycosyl Donor: The Key to Understanding the Outcome of Sialylation

Authors

  • Leonid O. Kononov,

    1. N. K. Kochetkov Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect, 47, 119991 Moscow, Russian Federation, Fax: +7-495-137-6148
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  • Nelly N. Malysheva,

    1. N. K. Kochetkov Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect, 47, 119991 Moscow, Russian Federation, Fax: +7-495-137-6148
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  • Elena G. Kononova,

    1. Laboratory of Molecular Spectroscopy, A. N. NesmeyanovInstitute of Organo-Element Compounds, Vavilova, 28, 119991 Moscow, Russian Federation
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  • Anna V. Orlova

    1. N. K. Kochetkov Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect, 47, 119991 Moscow, Russian Federation, Fax: +7-495-137-6148
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Abstract

Changes in the hydrogen-bonding pattern in solutions of glycosyl donor induced by the addition of external amides/imides or by concentration changes influence the yield and stereoselectivity of sialylation. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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