Dedicated to Prof. Peter Kutschy on the occasion of his 55th birthday
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Microreview
Synthetic Strategies Toward N-Functionalized Cyclens†
Article first published online: 25 AUG 2008
DOI: 10.1002/ejoc.200800636
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Suchý, M. and Hudson, R. H. E. (2008), Synthetic Strategies Toward N-Functionalized Cyclens. European Journal of Organic Chemistry, 2008: 4847–4865. doi: 10.1002/ejoc.200800636
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Publication History
- Issue published online: 25 SEP 2008
- Article first published online: 25 AUG 2008
- Manuscript Received: 27 JUN 2008
Funded by
- Ontario Institute for Cancer Research
- Abstract
- Article
- References
- Cited By
Keywords:
- Cyclen derivatives;
- Lanthanide chelation;
- Contrast agents
Graphical Abstract
Cyclen (1,4,7,10-tetraazadodecane) is a widely used building block in the synthesis of many important molecules with applications spanning MRI contrast agents,fluorescent probes and heavy metals sensors. This review describes the various synthetic methodologies employed for the preparation of N-functionalized cyclens.
Abstract
Cyclen (1,4,7,10-tetraazadodecane) is a widely used building block in the synthesis of many important molecules with applications spanning MRI contrast agents, fluorescent probes and heavy metals sensors. This review describes the various synthetic methodologies employed for the preparation of N-functionalized cyclens such as: synthesis from acyclic precursors; alkylation or acylation of cyclen; and protecting group manipulations. Emphasis is given to synthetic strategies allowing for the selective, differential N-functionalization of cyclen which is particularly useful for many modern applications.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)