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Keywords:

  • Natural products;
  • Fungal secondary metabolites;
  • Nodulisporins D–F;
  • Nodulisporium sp.;
  • Structural elucidation;
  • Bioactivity

Abstract

Six novel metabolites, nodulisporins D–F (13), (3S,4S,5R)-2,4,6-trimethyloct-6-ene-3,5-diol (4), 5-hydroxy-2-hydroxymethyl-4H-chromen-4-one (5) and 3-(2,3-dihydroxyphenoxy)butanoic acid (6) were isolated together with seven known compounds (713) from the culture extract of the endophytic fungus Nodulisporium sp. The relative configurations of these new compounds were determined by means of spectroscopic data, including HREIMS, 1H NMR, 13C NMR and 2D NMR (HMQC, HMBC and NOESY). The novel compounds exhibit antifungal and antialgal activities and most of them were also antibacterial.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)