Synthesis of the C11–C23 Fragment of the Potent Antitumor Agent Dictyostatin

Authors

  • Luiz C. Dias,

    1. Institute of Chemistry, University of Campinas, UNICAMP, P. O. Box 6154, 13084-971 Campinas, SP, Brazil, Fax: +55-19-3521-3023
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  • Dimas J. P. Lima,

    1. Institute of Chemistry, University of Campinas, UNICAMP, P. O. Box 6154, 13084-971 Campinas, SP, Brazil, Fax: +55-19-3521-3023
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  • Caroline C. S. Gonçalves,

    1. Institute of Chemistry, University of Campinas, UNICAMP, P. O. Box 6154, 13084-971 Campinas, SP, Brazil, Fax: +55-19-3521-3023
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  • Adriano D. Andricopulo

    1. Laboratório de Química Medicinal e Computacional, Centro de Biotecnologia Molecular Estrutural, Instituto de Física de São Carlos Universidade de São Paulo, Av. Trabalhador São-Carlense 400, 13560-970 São Carlos, SP, Brazil
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Abstract

We wish to report here our initial efforts toward the total synthesis of the potent antitumor agent dictyostatin, describing a short and efficient synthesis of the C11–C23 fragment. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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