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Keywords:

  • Malagashanine;
  • Strychnos;
  • Alkaloids;
  • Iminium;
  • Cascade;
  • Annulation;
  • Reaction mechanisms;
  • Polycycles;
  • Natural products

Abstract

A new cascade annulation reaction has been developed to access the core structures of a novel family of strychnos alkaloids with a unique stereochemical arrangement. The new annulation cascade is facilitated by the development of a robust reaction sequence to access extremely sensitive N-acyliminium ions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)